Vom Löwenherzig Rottweilers ~ Code of Ethics Rottweiler Kennel, Members USRC & ADRK, Rottweiler Breeder, German Rottweiler Bloodlines, Rottweiler Puppies, Schutzhund

OSTEOSARCOMA STUDY

Below is information regarding a very important cancer study (osteosarcoma) in Rottweilers. If you are eligible I urge
you to participate. This could help the future of our breed!

From: "Kenine Comstock" <keninec@med.umich.edu>
To: <cindyfive0@aol.com>
Sent: Friday, January 07, 2005 4:18 PM
Subject: Bone Cancer Study in Rottweilers

Hello,

We would greatly appreciate your help with this study. Eight thousand to 10,000 cases of bone cancer, also known as osteosarcoma,
are reported in dogs in the United States annually, representing a very significant health concern. Sadly, in the majority of cases, spread
of the tumor through the body and death follows within a few years. Osteosarcoma affects all dogs, but the disease frequency is
considerably higher in large and giant breeds, including Rottweilers. It has been suggested that genetics may play an important role in
this disease.

Our group of scientists have initiated a project to identify the genetic risk factors for osteosarcoma. This study is a collaboration
between University of Michigan, the Broad Insitute at MIT and Dr. Jaime Modiano at University of Colorado. We expect that this study
should lead to improvements in treatment of osteosarcoma. In addition, our findings will allow the development of genetic tests for
osteosarcoma.

We are collecting blood samples from Rottweilers that have been diagnosed with osteosarcoma. We do need a copy of the pathology
report describing how the diagnosis was made. We are requiring a biopsy be done for the study. Contact us prior to having the biopsy
done and we can give specific instructions. We also need a copy of the pedigree through the grandparents.

Those fortunate owners with healthy dogs can also help. In addition, we are collecting blood samples from healthy dogs who are over
6 years old and have never been diagnosed with cancer. Again, we need a copy of the pedigree through the grandparents.
Participating dogs should not be related as far back as their grandparents, so please don't send any you know to be related.

To participate in the study, Rottweiler owners can simply request a collection kit from us, take their dog to their own veterinarian to
have the blood samples drawn, and then send the sample back to us . If you would like to request a kit or any further information
about the
study or collection process, feel free to contact me.

Warmest regards,
Kenine

Kenine E Comstock, Ph.D
University of Michigan
5121 Cancer Center
1500 E Medical Center Dr.
Ann Arbor MI 48109

734-647-7417 (phone)
734-647-5470 (fax)

Samantha & Steven Canuso
Douglassville, PA
(1 hour north of Philadelphia)
610-639-4066 (9 AM to 9 PM ET)
w orkingrott @vomlowenherzigrottweilers .com

Pricing information will not be given out via e-mail.
No phone calls on Sunday or holidays please.
We have children, so please no phone calls before or after the hours listed above.
Due to time constraints, we cannot discuss our dogs in great detail via email. Please call us for detailed discussions.

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